GEVALT - GEVALT
(GEnotype Visualization and ALgorithmic Tool) is designed to simplify
and
expedite the
process of genotype analysis and disease association tests by providing
a common interface to several common tasks
relating to such analyses.
It is aimed for analysis of unrelated individuals as well as
two-generation families.
RAT - RAT
(Rapid Association Test) is a software for testing association between
single nucleotide polymorphisms (SNPs) and a disease. The main
advantage of RAT is its ability to calculate accurately and quickly
high significance disease association. For large data set and low
p-values, RAT is 2-4 orders of magnitude faster than the standard
permutation test. The software is written in C++, and can be used
under both Linux and Windows platforms.
PSAT
- PSAT (Population Stratification Association Test) is a software for
testing association between single nucleotide polymorphisms (SNPs) and
a disease with stratification. The approach is a randomization test
akin to a standard permutation test. It conditions on the
genotype matrix and thus takes account not only of the population
structure but also of the complex linkage disequilibrium structure of
the genome. The main advantage of PSAT is its ability to calculate
accurately and quickly high significance disease association. The
software is written in C++. Binary versions of PSAT are ready for Linux
and Windows platforms.
The software is based on an algorithm described
in the following paper:
Gad Kimmel, Michael I. Jordan, Eran
Halperin, Ron Shamir and Richard M. Karp.
A randomization test for controlling population stratification
in whole-genome association studies.
To appear in American Journal of
Human Genetics, 2007.