CS298-4, Seminar on Self-Assembly
PREVIOUS
< - - - - > CS 298-4 HOME < - - - - >
CURRENT
< - - - - >
NEXT
Monday November 28, 2005, 4:10pm-5:30pm,
in 380 Soda Hall.
"Mathematical Modeling of Planar Cell Polarity in the Drosophila Wing"
Joint work with Keith Amonlirdviman, Ronojoy Ghosh, Dali Ma, and Jeff
Axelrod
ABSTRACT:
In this talk, methods that we have designed to analyze and help to
identify certain protein regulatory networks will be presented. Often,
only incomplete abstracted hypotheses exist to
explain observed complex patterning and functions in cellular regulatory
networks. I will present our results in
developing a mathematical model for Planar
Cell Polarity signaling in fly wings. We explicitly demonstrate that
the model can explain the complex behaviors of the system, and can be
used to test developmental hypotheses, such as the function of
certain protein alleles, and the relationship between cell geometry and
polarity.
Here are some background reading materials:
K. Amonlirdviman, N. A. Khare, D. R. P. Tree, W.-S. Chen, J. D. Axelrod,
and C. J. Tomlin. "Mathematical Modeling of Planar Cell Polarity to
Understand Domineering Nonautonomy." Science 307 5708:423-426, 21 Jan
2005.
PDF: http://sun-valley.stanford.edu/~tomlin/BIO/423.pdf
Supporting Online Material:
http://sun-valley.stanford.edu/~tomlin/BIO/Amonlirdviman-etal-SOM_lowquality.pdf
Symbolic Reachable Set Computation of Piecewise Affine Hybrid Automata and
its Application to Biological Modelling: Delta-Notch Protein Signalling
Ronojoy Ghosh and Claire Tomlin
Systems Biology, 1(1):170-183
June 2004
PDF: http://sun-valley.stanford.edu/~tomlin/BIO/sysbio_ghosh_tomlin.pdf
Page Editor: Carlo H. Séquin