MetMap
Inference of Site-Specific Methylation from MethylSeq Experiments
MetMap is a computational pipeline for the analysis of MethylSeq experiments. MethylSeq involves digestion of the genome with the HpaII restriction enzyme and high-throughput sequencing of the fragments' ends. MetMap can be used with any genome for which a reference sequence is available.
Starting from MethylSeq data, MetMap outputs (1) site-specific methylation probabilities for all restriction sites, (2) coordinates of Strongly UnMethylated Islands(SUMIs), and (3) lists of sites that are suitable for intra- and inter-species comparisons.
If you use MetMap, please cite:
Meromit Singer, Dario Boffelli, Joseph Dhahbi, Alexander Schönhuth, Gary P. Schroth, David I.K. Martin and Lior Pachter, MetMap enables genome-scale methyltyping for determining methylation states in populations, PLoS Comp. Bio. doi:10.1371/journal.pcbi.1000888
Acknowledgments:
MetMap was conceived and developed by Meromit Singer.
MetMap v2.0 was programmed and implemented by Thurston Dang.
Download MetMap 2.0: